Is it True that Inactivated Vaccines are Safer with less Side Effects?

Many has the opinion that inactivated vaccines are safer. They claimed that unlike the other vaccines, Sinovac has lesser serious adverse side effects.  Let find out in this paper.

 
What is Inactivated Vaccine?

It is just another type of vaccine, mostly using dead viruses cultivated from some organs such as Monkey’s kidney cell or otherwise, just like how they cultivated Poliovaccine before

The production of inactivated poliovaccine on serially cultivated kidney cells from captive-bred monkeys 

https://pubmed.ncbi.nlm.nih.gov/6244995/

 

Any Proof about the Side Effects?

There are tons of report about side effects on many other types of vaccine especially mRNA vaccines but never much news about those inactivated vaccine for some unknown reasons.  There were much talks about vaccine manufacturers always have non-disclosure agreement signed with the countries before agreeing to supply the vaccines.   So,  not hearing much about the side effects does not mean the  vaccines are safer.  

Let’s examine the Sinovac’s reports submitted to WHO for approval in April 2021.  This is the copy. https://cdn.who.int/media/docs/default-source/immunization/sage/2021/april/4_sage29apr2021_sinovac.pdf?sfvrsn=2d82605d_5

Inside the report, there are several report lodged by various testing institutions.  One the reports from Brazil has this chart (click picture to enlarge)

Misconception: Home, Safest Place away from Covid

The report said there were 77.1% of those vaccinated suffering from adverse reaction.  This figure is higher than the 66.37% in the unvaccinated group.  The type of adverse effect is tabulate here for comparison:

If we were to discount those common symptoms (colored blue) which is about 57% for both vaccinated and unvaccinated,  the more serious side effect will be 42.78% for vaccinated and 43% for the unvaccinated as shown in the table.

Other independent report published in Lancet also showing similar results in the Phase 2 trial test.  They showed Sinovac were having higher % in the common adverse effect but the % is lower than the report showed by the Brazilians.

  https://www.thelancet.com/article/S1473-3099(20)30843-4/fulltext 

Interesting Chart About Sinovac

The above chart shows that those vaccinated has a pyramid covering up the Grade 3.  On the other hand,  those unvaccinated has similar pyramid but covering up also grade 4 to grade 6.  This grade 4 to grade 6 is for those suffering moderate or severe hospitalization and ICU.  The chart showed that there were about 83.70% of those vaccinated and unvaccinated group had mild grade1 to grade3 symptom.  About  33% (83.7%-50.65%) of them requiring medical attention.

Second WHO submission

The first submission to WHO was also in April.  This was the submission report.

https://cdn.who.int/media/docs/default-source/immunization/sage/2021/april/5_sage29apr2021_critical-evidence_sinovac.pdf