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Monday, June 7, 2021

Why They Said Some Brands of Vaccine were Not Effective?

4 June 2021

(Updated 8 June 2021)

"The Week" has this news article. It said that "the Chinese's Covid-19 vaccines appears not effective." Is this true? Why they are saying so? Do they have any reason? This article will describe a simple method where one can use to verify if what they are saying is really true.  

About The Week 

First, about "The Week". This is a weekly news magazine with editions in the United Kingdom and United States. Although it is a bit left biased, most media rating agencies rated them as unlikely to give fake news. The following is its news report on 4 June 2021. 

https://theweek.com/china/1001165/chinas-covid-19-vaccines-dont-appear-to-be-effective-in-preventing-outbreaks-in-the


 

 Responses

Netizens have mixed views. Those in favour of conventional vaccines like the inactivated vaccines have not agreed. They insisted that this news was very biased.  Some said "This Week" was reporting fake news.  Lets examine this news with real World data from "Our World in Data"

How to Examine?

We can use available charts in "Our World in Data". One of them is "the number of people who received at least one dose of COVID-19 vaccine' as shown on the left. The other is the 7-day rolling average of "Daily new confirmed cases per million people" . it is as shown in on the right. These 2 charts are arranged side by side for easy reading. The one on the left shows how much 1st dose vaccines have been given. Effective vaccine should bring down the rate of daily new confirmed infection shown on the left.

(Note: The following 2 charts for infection and death rate are interactive. One can change and add countries to get the desired results. The followings are countries that has been most affected by Delta)



The other chart that will be useful for comparison is   "Share of people receiving at least one dose of vaccine vs Daily Deaths Per Million People. This chart tells if the vaccines are effective to curb death rate in the country.



Putting 3 Chart Together

It will be clearer at times to put the above charts together for comparison purpose
(Note: these chart are interactive. Change the country name as wished. Clikc remove side bar for larger view plus many more charts)





User Note on How to Navigate

1. Select the country by clicking the text button "+Add country". Then tick the appropriate check boxes. The chart will update automatically;

2 Note that the charts are not of the same horizontal scale. To compare, adjust the scale on the right hand chart. This is done by draging the scale at the bottom of the chart using the mouse;

3. The death rate would be more realistic than infection rate. The infection rate can be lowered if country has not done enough testings. Refer to Worldometer for testing frequency.

Chart Interpretation

Take UK US & Israel for example,  we can roughly say their vaccines are working to tame the infection. Their infection rates came down as soon as the vaccination numbers went up.


For Bahrain & Uruguay, there is still no sign that the infection rate has been tamed at all.   These countries will need to check if their vaccines are able to deal with the Covid-19 variants.



As for the case in Brazil and Chile, they managed to hold the infection rate. There is still no sign about when will they be able to tame the viruses.  Chile might have a vaccine that is not able to tame the Covid-19 variant.


The situation in Seychelles is not much different from the rest of the other countries. This tiny Easteern African island in the Indian Ocean has a volatile infection rate.



Some claimed Turkey and Hungary using inactivated vaccines.  They also tamed the vaccine successfully.  This "story" is not quite true.  Turkey used about 20-30 millions of Sinovac before April & they have more Pfizer now with supplies totalling 120 millions doses.  As for Hungary,  they have supplies from European Union until May;  by then,  the infection was almost over.


Take Away

Vaccines are highly politicized by various countries. This article describes only a simple method on how to check the effectiveness of vaccine using available public information. For those interested to know what brands of vaccine these countries are using, please refer to this webpage.   One can also find out how many of which type of vaccines have been used to-date by some countries in terms of numbers and % from the webpage.

This simple method is to give an idea on how one could judge if the vaccines are effective. Previously before we have vaccines,  many countries like China,  Singapore, Japan, Australia, New Zealand & Taiwan were able to tame Covid-19 using the traditional control methods. These methods are Covid-19 testings,  mask wearings,  quarantine, safe distancing & shutdowns.    

 https://tinyurl.com/v8j3b3t9



Wednesday, June 2, 2021

Coronavaccine Really Works?

 2 June 2021

 
This question was always in some people's mind.  We are hearing people saying "You can bluff and lie,  Covid-19 will prove you wrong"  

In this article,  lets explore some real World cases using graphs and data from Our World Data.

Cases in United Kingdom & United States

We heard many stories about how UK and US have tamed Covid-19.  These 2 countries have relaxed their Covid-19 protection guidelines. They are no longer insisting their residents to wear mask under certain conditions. They are also relaxing the social gathering & distancing rules. 

Lets examine their vaccination rate and infection rate to-date in these 2 charts.   If the vaccine is effective,  it will definitely help to bring down the infection rate

a) Daily COVID-19 vaccinations administered per 100 people


 Visit here for more charts and information

 b)  Daily new confirmed COVID-19 cases per million people




  Visit here for more charts and information

Unfortunately,  it is hard to digest the above chart because they are in different scales.  Lets superimpose the 2 charts and bring them in line as shown in the following chart

 

One could immediately see that in the case of UK and US,  the vaccine has brought down infection rates. The infection rate was a high of over 600-800 case per million people in early Jan 2021. Now it is only 40 cases per million people in Jun 2021 which is a 93% cut.  This is despite UK and United States have reduced the of vaccination rate about 2 to 3 months ago. They cut the rate in March to April 2021 from 80-90 per 100 people  to the present rate of less than 30 per 100 people in US.

In Conclusion

One can say that vaccine does work to bring down the Covid-19 infection rate as far as UK and US are concerned.  On how long this will  continue to work  will depend how fierce will be the coronavirus variants.  Science is telling us that virus will always mutate. They will mutate into a new kind of virus that will resist existing vaccines. 

In here, one can find out what brands of vaccines used in various countries. The webpage contains an interactive chart, providing some information about the vaccine brands. 

Doubleclick here or the picture for interactive chart



https://tinyurl.com/4yx5987c



Update: 10 June 2021

Here is a better way to compare the effectiveness of vaccines being deployed in various countries.   Not all vaccines are equally effective.  Some can tame Covid-19.  Some are struggling even without the attack of new variants which are more vicious and infectious. 

 https://tinyurl.com/v8j3b3t9 







 







Wednesday, May 26, 2021

Does Vaccine Efficacy Really Matter?

22 May 2021

Discussion about Covid-19 vaccine is super hot nowadays. There is a vaccine shortage at present. Many countries are chasing after available vaccines. Even many of those not yet approved by World Health Organization (WHO) are snapped up. Why it is so?

To convince their people to take vaccine, some countries claimed the vaccines are safe & effective. Some even provide incentives to promote vaccination. This is despite there is still no approval from WHO. They are creating free publicity for the vaccine manufacturers. Why it is so?


Why?

To understand better, we'll do some simple maths. We will compare the cost of vaccines vs traditional measures to control the virus spread.

There was an outbreak recently in Singapore. A new variant called B1.167 created havoc. It infected about 400 people within a short span of a month. To control the spread, Singapore Government tested about 400,000 people. They were suspected to have close contact with the infected person. This 400,000 works out to roughly 1,000 tests per infected person.

The following table will show that it will be more cost effective for the Government to opt for vaccine. Besides being less disruptive, the effect of vaccine will last much longer.  Note that the cost excluded  treatment and all other cost which could be quite substantial as well for the traditional control method.



What Does Vaccine Efficacy Means?

Vaccine effectiveness is often measured by the term called vaccine efficacy.  It is worked out by using this standard formula.


Vaccine manufacturers are required to carry out their trials in 3 phases. Phase 1 & 2 are for testing out the safety whereas Phase 3 trial requires  30,000 people or volunteers. These people are divided into 2 groups, one fully vaccinated and the other without. These people shall live in a controlled community. They are required to live and work in virus infected environment. Their conditions are monitored in regular intervals. At the end of Phase 3 trial, their virus attack rates are used to work out the efficacy using the standard formula.


Does Vaccine Efficacy Really Matters?

There is no medicinal cure for any type of viruses found today. Viruses are known to mutate & survive in new & tougher environment.  The new variants are also known to be more infectious. One can imagine what it would be like when a vaccine  cannot "kill” and wipe out the entire virus colony.


How Vaccine Efficacy Matters?

Take the case in Singapore again. The present outbreak had 78 infected among the 400 people.  These 78 people  had full dose of vaccine. This translated to a total testing cost of about SGD$72 millions as shown earlier.   This was because the vaccines used in Singapore has a vaccine efficacy of 95% . What would this testing cost if the efficacy was 60%?

To work out this number, we can use the efficacy calculation template as shown in this webpage. We can change the number in row 10 or the "number of fulldose infected". Now,  if we change this row 10 number to 320 instead of 78, we should get the vaccine efficacy number to be roughly 60%. 


    In other words, if Singapore's vaccine were 60% and not 95%,   Singapore Government would have to spend another $57 millions on testing cost. The total testing cost would then be $129 millions and not $72 millions. 

     Using the same method by changing the numbers in row 10,  we can plot this following chart that will show the vaccine efficacy vs % vaccinated people infected.  


In conclusion,  Vaccine efficacy really matters.  To control the spread of Covid-19 using vaccine of lower efficacy will jack the testing cost by inversely proportional amount. 

 

https://tinyurl.com/jnbkephp

Saturday, May 22, 2021

Important & Significant Covid-19 Data

22 May 2021

Please use dropdown box to select chart to view

Note:   These are interactive charts displayed with courtesy of ourworldindata.org.  They are extracted and embed here for easy reference.  User can "Add Country" to change the country name etc to get the required information

1) The percentage of population receiving at least one dose of COVID-19 vaccine  

This data is significant because it indicates if a country is able to contain the spread of the virus. To contain the spread, adequate number of people must be vaccinated. This number in % of total population is often referred to as the threshold of herd immunity. This is the level where one can expect the spread of disease will start to decline. Different diseases have different threshold of herd immunity. For Covid-19, this level has not been established yet. But many experts believe it to be around 60% to 75%. For Polios & smallpox, it was 80% to 86% and for measles, 92%-95%. 

The 1st dose figure is more significant than full dose figures. Some have been quoting vaccination in terms of per million people. This figure unfortunately could not tell if a country is in a position to stop the spread of the virus.

  

 This chart is the vaccination rate among ASEAN countries



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2.  Daily COVID-19 vaccinations administered per 100 people

This figure is important as it shows what is the present day vaccination rate.  A lower figure will take the country longer time to reach the threshold of herd immunity which is around 60%-80%.

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3.  COVID-19 vaccine doses administered

This is a good to have chart to find out how many doses have been administered in a country.  The country with higher population will show a higher number.  It will not show if the threshold of herd immunity has been reached and the country is safe from infection.

 

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4. Daily new confirmed COVID-19 cases

This figure are often used to judge if there is a reduction in the rate of infection. However,  this figure is not quite significant. It could not also tell if the control measures are effective. This is because there are too many variable in the real World..

   

 

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5.  Daily new confirmed COVID-19 cases per million people

Similar to daily new confirmed COVID-19 cases,  this figure is important to get a sensation feeling but not quite significant. Good to know how country is doing.  With the information of % vaccine doses given,  one can also tell roughly if their vaccines were working to control covid-19.

 


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6.  Daily new confirmed COVID-19 deaths per million people

Similar to daily new confirmed COVID-19 cases,  this figure is important to get a sensation feeling but not quite significant. Good to know how country is doing.  With the information of % vaccine doses given,  one can also tell roughly if their vaccines were working to control covid-19.

 


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7.  Number or % infected having full vaccination


This figure is quite important and significant. It might be able to tell how effective is the vaccine deployed by each country.  Unfortunately,  this figure is not easily available. This is because the figure will not help as many people vaccinated as possible. 

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8.  The Growth Rate in % Against the Average

This figure is also important. It will tell whether a country has been successful in implementing its vaccination program.  The % of people vaccinated will  always decline with time.  There will come a time when people will loose interest. Either they have been vaccinated or they do not believe in vaccine.  For example,  Hong Kong's vaccination rate has come down lately. It is not healthy if the city has rising case of infection in the early days;  fortunately,  this is not the case. This kind of information is not easily available.

 

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Note:   These are interactive chart with courtesy of ourworldindata.org.  They are extracted and embed here for easy reference.  User can "Add Country" to change the country name etc to get the required information

9.  Cumulative Numbers of Infected People and of those having taken Full Dose

This numbers are important because one can use it to work out the attack rate for the selected window as shown in the example of how to determine the vaccine efficacy

a)  The Cumulative Number of Infected People

 

 b) Total number of People having taken Full Dose


https://tinyurl.com/45k5tp78

Tuesday, May 18, 2021

How To Estimate the Efficacy of The Vaccine

18 May 2021
(Updated 14 June 2021:  Added UK Data)
 
If you receive this piece of news, what would you think?

The news is about Seychelles,  a small island country somewhere in Indian Ocean. The paper said this small nation has 37% of the infected people fully vaccinated.
 

To some,  this is really a shocking piece of news.  To others,  they might "brush it off" claiming it is just another fake news.  Unless the vaccine is useless, it is hard to believe. How come one can get infected so easily when one already has the  full 2 doses of vaccine. 
 
Now, what exactly does that News report really mean?


Vaccine Efficacy 

“Vaccine efficacy” is a familiar term nowadays.  It simply tell how effective is a vaccine in reducing the virus infection.   If we say Seychelles' vaccines have a combined efficacy of 60%,  one will quickly understand that the vaccines are actually workingJust that the vaccines are not having very high efficacy.  It is as claimed by some countries. We have also an infectious African variant,  B1351,  "roaming" around.  This efficacy is still above the threshold of 50% set by WHO for approval under emergency usage.  The question now is how to roughly work out this 60% efficacy without all those laboratory tests and trials ?
 

Efficacy Measurement

The vaccine efficacy is always worked out by carrying out the tests in a laboratory or otherwise under controlled environment. This is to ensure the variables that will affect accuracy are kept to a minimum. In the real World, it is unlikely to accurately measure the efficacy vaccine.  This is because one will know how many people have been infect and there is no way to tell how many were exposed to the virus. But there is nothing to stop us from estimating the "Vaccine Efficacy" or usually termed as "Vaccine Effectiveness" for the purpose of knowing if the vaccines we have taken are in order 

 

How to Estimate the Effectiveness?

Take the case in Seychelles for example, in the news report, we can gather the following information:-

1.  37% of those infected people were fully dosed 

2.  The seven day rolling average of positive cases increased from 120 on April 30 to 314 on May 8

3.  Nearly 60% of the population have had two doses. (about 66% in other news report) 

From some other websites, we can also find the following information

1. The total population of Seychelles is 97,625

2. This Reuters news report is on 12 May 2021

We can also gather these information from this page or alternatively,  from graphics.reuters.com & www.worldometers.info.

1. The total number of infection between Jan 12 and May 11 2021 is 7,571;

2. Seychelles’ vaccine roll out date is 12 Jan 2021

Equipped with these information, we can now roughly work out the attack rates of those vaccinated (ARV) and unvaccinated (ARU) .  

Finally, using the standard Efficacy rate of the Vaccine formula, we can work out the rough effectiveness for the vaccines used in Seychelles.  This is roughly 60.70% as shown in this example sheet

 


Similarly,  we can also work out the vaccine effectiveness roughly for other countries and a copy of which is shown in this table

Interactive Template

One can use the follow template to estimate the rough effectiveness in your country if you also have the required information 

(Note:  Please doubleclick the following image to be re-directed to the calculation template or Just click this link )

UK Example  Updated (11 Jun 2021) 

UK Public Health released a report on the effect of Covid-19 Variants.  It has this table 6 on page 15 reported about infection &  deaths of Delta (Indian Variant) confirmed cases from 1 February 2021 to 7 June 2021. 

The report said 9,344 vaccinated people were infected,  among them 1,785 has full 2-doses.    Using this information,  we could roughly estimated the UK's vaccine efficacy to be about 74% for all vaccinated,  93% for those having full doses only & 68% if we were to include only the vaccinated & unvaccinated. 

Note: This is the efficacy estimate only against Delta variants



About the Method

This is a simple example.  The aim is to give users a reference to  work out roughly and compare the combined vaccine effectiveness.   The example uses the "window" between rollout date and the breakthrough date.   Users can always choose other "windows" if the information are available. 

In the  real World,  there is always a difficulty getting the numbers for the people exposing to the disease,  especially for those unvaccinated. This information are required to work out the attack rates. 

It is a common knowledge that in the real World,  the vaccinated and unvaccinated are not living & working together . Their risk of exposure to the virus are much different.  Any attempt to estimate the vaccine efficacy over a short period &  over a sudden spike can be misleading.

Take the case that happened in Singapore in recent weeks. 78 people with full doses among some 400 others were found infected. Attempt to use these information to work out the vaccine efficacy will yield misleading result. This is because most of the 78 vaccinated were front-line staff.  Their exposure to virus will be much higher than those unvaccinated whom they were serving.

 https://tinyurl.com/u2ts2hfn


Monday, May 17, 2021

Coronavirus Vaccine Tracker (Nos of Countries using Vaccine)

17 May 2021

 


Various countries have approved 15 vaccines so far for emergency use. About 60 of other brands are still in various development stage. Out of the 15 vaccines approved for use,  WHO, The World Health Organization has only approved 6 of them. This is as shown in the following table. 

 




Vaccine Approvals 

It is not mandatory for country to use vaccines approved by WHO. Individual country has own list and approval guidelines. 

The number of countries that have approved the use of various brands of vaccine are shown in this 3D Pie Chart. 
 
>

https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker

This 3D Pie chart shows that the 4 US vaccine manufacturers  have the approval from most countries.  One of the reason for the bigger share must be because their vaccines have better efficacy.
 

Market Rumours

There are lots of rumours in the market about which vaccine is better. Some rumours claimed that the Chinese or Indian vaccines are the best. They said the mRNA vaccines offered by Pfizer and Moderna are not the traditional type. Hence, not quite safe. There are also claims that mRNA vaccines have more severe side effects.

Some even claimed Sinovac and Sinopharm have better protection against death and hospitalization. This is despite they have lower efficacy.  
 
As most claims did not have data to back them up.   Also there is no World standard for the measurement, this article will not discuss them.  
 
Presently, there is only one acceptable measurement. That is the the measurement of efficacy for the vaccine.

What Exactly is Efficacy?

Efficacy is a measurement that tells how well the vaccine can reduce a disease infection.  It is worked out by comparing the infection rate or attack rate of some 30,000 recipients.  These recipients are divided into 2 groups,  one vaccinated and the other unvaccinated.  They worked  and lived in a community under a controlled environment.  Their conditions were monitored and their blood samples taken regularly to measure the virus attacks.   

There are also 2 other terms that are often mentioned. These 2 terms are effectiveness & efficiency of the vaccine. Presently, there is no such acceptable measurement standards available.
.

The Efficacy of Various Brands of Vaccine

The Economist has a very good chart showing the efficacy of various brands.     This chart shows that Sinovac's efficacy is too close to WHO's 50% threshold for listing of vaccines for emergency use.














https://www.economist.com/graphic-detail/2021/04/15/in-clinical-and-real-world-trials-chinas-sinovac-underperforms#

Find out which Country use what vaccine most

The Our-World-in-Data has this chart that one can check what countries use what type of vaccine and how much of it.  The chart is reproduced here


Translate the chart into numbers,  one will get the following tables





Should One Wait for Better Vaccine?

Every country is now chasing after available vaccines.  As a result,  vaccine is in very short supply. The advice generally is to take whatever vaccine available. This is because the vaccine of choice might never come.

There were fierce debates among Scientists whether one can switch to other brands. There were no decision as there was not enough data to back up the claim.  Nonetheless,  some recipients in some countries took different brands by mistakes.  There were no adverse reports lodged. It would appear likely that switching to other brands might be a possibility.

https://tinyurl.com/3uwpn5wa

Sunday, May 16, 2021

How To Embed Twitter Videos in BB Forums & Blogs

16 May 2021

How To Embed Twitter Videos in BB Forums & Blogs

Twitter allows embedding of its videos in various kinds internet medias and discussion. But, it is not easy to have them embedded in a BB Forums. This is because most BB Forums accept only iframe codes. This article will offer a method where users can get twitter video embedded in such forums

What you need?

This iframe code

<iframe src="https://twitframe.com/show?url= https://twitter.com/i/status/1289954190756782080" style="border:0px #ffffff none;" name="myiFrame" scrolling="no" frameborder="1" marginheight="0px" marginwidth="0px" height="850px" width="600px" allowfullscreen></iframe>

This code will work as long as https://twitframe.com/ is not down.

How to Embed?

Just right click any twitter video and copy the video address. Then paste it to replace the url address shown in the above example.  After that,  just simply copy the whole iframe code and paste it to the BB Forums or put the iframe code as a script in the HTML page of the blog.

Is this Legal?

It is perfectly legal as twitter does allow copying of the video for embedding in webpages. The iframe code is just an alternative mean of embedding the video

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